Opportunity Information: Apply for DE FOA 0002059
The Department of Energy (DOE) Office of Science, through its Biological and Environmental Research (BER) program, released a discretionary grant funding opportunity titled "Systems Biology Enabled Research on the Roles of Microbiomes in Nutrient Cycling Processes" (Funding Opportunity Number: DE-FOA-0002059). The opportunity sits within the mission space of DOE's Genomic Science Program (GSP) and is focused on advancing fundamental, systems-level understanding of how microbes and microbiomes drive nutrient cycling in terrestrial environments. In practical terms, DOE is looking to fund research that explains how microbial life, alone and in communities, regulates the movement and transformation of nutrients through soils and ecosystems, and how these processes connect to broader biogeochemical cycles.
The FOA emphasizes two main research directions. First, it seeks systems biology investigations of the regulatory, metabolic, and signaling networks that operate in microbes, microbial consortia, and microbe-plant interactions when they participate in nutrient cycling. This includes studies that move beyond identifying "who is there" to uncovering "what they are doing" and "how it is controlled," such as mapping pathway regulation, metabolite exchange, cellular communication, and coordinated behavior across organisms. A key element is the network-level perspective: DOE is encouraging work that integrates multiple layers of biology to explain functional outcomes relevant to nutrient transformations, rather than isolated single-gene or single-organism descriptions.
Second, the FOA calls for the development and application of "-omics" approaches (for example, genomics, transcriptomics, proteomics, metabolomics, and related high-throughput methods) to investigate microbial community processes involved in nutrient cycling in terrestrial ecosystems. This track is aimed at enabling or improving the tools and data-driven strategies used to measure and interpret community function at scale, particularly in complex natural settings like soils and plant-associated environments. The intent is to strengthen the ability to connect molecular-level measurements to ecosystem-relevant nutrient cycling processes, including community interactions and emergent behaviors that cannot be captured by studying organisms in isolation.
From an administrative standpoint, this is a DOE Office of Science grant program categorized under Science and Technology and other Research and Development (CFDA/Assistance Listing: 81.049). Eligibility is listed as unrestricted, meaning applications are open to a broad range of entity types, with the standard caveat that any specific constraints would be described in the FOA's eligibility details. The announcement was created on February 11, 2019, with an original application deadline of May 17, 2019. DOE anticipated making about 11 awards, with an award ceiling of $3,750,000 per project.
Overall, the opportunity is designed to support fundamental research that benefits the public by increasing understanding of the natural world, specifically the biological mechanisms and community dynamics that govern nutrient cycling in terrestrial ecosystems. The focus on systems biology and multi-omics signals DOE's interest in integrated, mechanistic, and predictive science that can explain how microbiomes function and respond to environmental conditions, especially through the lens of nutrient transformations and biogeochemical cycling.Apply for DE FOA 0002059
- The Department of Energy - Office of Science, Office of Science in the science and technology and other research and development sector is offering a public funding opportunity titled "Systems Biology Enabled Research onthe Roles of Microbiomes in Nutrient Cycling Processes" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 81.049.
- This funding opportunity was created on Feb 11, 2019.
- Applicants must submit their applications by May 17, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $3,750,000.00 in funding.
- The number of recipients for this funding is limited to 11 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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