Opportunity Information: Apply for PAR 16 455
This NIH funding opportunity, titled "Multi-Site Studies for System-Level Implementation of Substance Use Prevention and Treatment Services (R01)" (Funding Opportunity Number PAR-16-455), supports large, multi-site research projects focused on how to put proven substance use prevention and treatment approaches into practice at the systems level. It sits within the Collaborative Research on Addiction at NIH (CRAN) initiative and is jointly issued by the National Institute on Drug Abuse (NIDA), the National Institute on Alcohol Abuse and Alcoholism (NIAAA), and the National Cancer Institute (NCI). The central idea is not to re-prove whether an intervention works in a tightly controlled setting, but to develop and rigorously test implementation interventions, models, and/or frameworks that improve how evidence-based services are delivered in real-world organizations and systems.
The scope emphasizes system-level implementation, meaning research should look at policies, organizational structures, workflows, financing, cross-agency coordination, and other higher-level factors that shape whether evidence-based prevention and treatment services are actually adopted, delivered well, and sustained over time. Projects are expected to examine ways to improve delivery, uptake, quality, and sustainability of evidence-based interventions, guidelines, or principles for substance use prevention and treatment. In practice, this often implies studies that compare implementation strategies across multiple sites, evaluate how different system contexts affect outcomes, and identify scalable approaches that can be replicated across settings such as healthcare systems, behavioral health networks, schools, justice settings, community programs, or other service environments where prevention and treatment occur.
The mechanism is an R01 research project grant, and the opportunity is categorized as discretionary funding. The activity area is listed under Education and Health, and the CFDA numbers associated with it are 93.273, 93.279, and 93.399. The opportunity includes an award ceiling of $500,000 (as provided in the source data). The original closing date listed is 2018-01-24, and the posting (creation) date is 2016-09-30, which signals this is a historically dated notice; anyone interested would typically need to verify whether the FOA is still active, has been reissued, or has been replaced by a newer announcement.
Eligibility is broad and includes many common U.S.-based applicant types: state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments (federally recognized); public housing authorities/Indian housing authorities; Native American tribal organizations other than federally recognized tribal governments; nonprofit organizations with or without 501(c)(3) status (when they are not institutions of higher education); for-profit organizations other than small businesses; small businesses; and other eligible entities. The FOA also explicitly highlights additional eligible applicants such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible agencies of the federal government, regional organizations, Indian/Native American tribal governments that are not federally recognized, and U.S. territories or possessions.
At the same time, the opportunity draws clear boundaries around foreign participation. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply. Non-domestic components of U.S. organizations are also not eligible to apply, and foreign components, as defined by the NIH Grants Policy Statement, are not allowed. In other words, projects must be fully domestic in terms of applicant and participating components under NIH definitions, even if the research has implications that extend beyond the U.S.
Overall, the grant is designed for investigators and teams who can run coordinated, multi-site implementation studies that test how systems can reliably deliver evidence-based substance use prevention and treatment. A competitive application would generally be expected to show strong partnerships with real-world service systems, a clear implementation approach or strategy to be tested, practical and measurable outcomes related to adoption and quality of services, and a plan for sustaining effective changes after the research period ends, all while leveraging the strengths of multi-site designs to generate findings that generalize across settings.Apply for PAR 16 455
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Multi-Site Studies for System-Level Implementation of Substance Use Prevention and Treatment Services (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.273, 93.279, 93.399.
- This funding opportunity was created on 2016-09-30.
- Applicants must submit their applications by 2018-01-24. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $500,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Collaborative Consortia for the Study of HIV Associated Cancers: U.S. and Low-and Middle-Income Country Partnerships (U54) Apply for RFA CA 16 018 Funding Number: RFA CA 16 018 Agency: National Institutes of Health Category: Education, Health Funding Amount: $600,000 |
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| Self-Management Interventions and Technologies to Sustain Health and Optimize Functional Capabilities (R21) Apply for PA 17 011 Funding Number: PA 17 011 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Improving Individual and Family Outcomes through Continuity and Coordination of Care in Hospice (R01) Apply for PA 17 016 Funding Number: PA 17 016 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Palliative Care Needs of Individuals with Advanced Rare Diseases and Their Family Caregivers (R01) Apply for PA 17 018 Funding Number: PA 17 018 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Palliative Care Needs of Individuals with Rare Advanced Diseases and Their Family Caregivers (R21) Apply for PA 17 017 Funding Number: PA 17 017 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Use of Technology to Enhance Patient Outcomes and Prevent Illness (R01) Apply for PA 17 010 Funding Number: PA 17 010 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Nicotinic Immune Modulation in the Presence of HIV-1 Infection (R01) Apply for RFA DA 17 020 Funding Number: RFA DA 17 020 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Improving Quality of Care and Quality of Life for Persons with Alzheimers Disease and Related Dementias at the End of Life (R01) Apply for PAS 17 027 Funding Number: PAS 17 027 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Improving Quality of Care and Quality of Life for Persons with Alzheimers Disease and Related Dementias at the End of Life (R03) Apply for PAS 17 026 Funding Number: PAS 17 026 Agency: National Institutes of Health Category: Education, Health Funding Amount: $50,000 |
| NCI Research Specialist (Core-based Scientist) Award (R50) Apply for PAR 17 050 Funding Number: PAR 17 050 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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