Opportunity Information: Apply for RFA HL 17 021
The Cardiovascular and Pulmonary Research on E-Cigarettes (R01) funding opportunity (RFA-HL-17-021) is a National Institutes of Health discretionary research grant designed to spur rigorous, non-cancer-focused research on how electronic cigarette exposure affects the heart, blood vessels, and lungs. The central aim is to build clearer evidence on cardiovascular and pulmonary physiologic and health outcomes linked to e-cigarette use, including effects that may occur in either system alone or through combined heart-lung interactions. The announcement is broad by design and encourages investigators to address real-world questions about exposure and harm mechanisms rather than limiting studies to a single product type, population, or experimental approach.
The FOA welcomes a wide range of scientific strategies and study settings, including research conducted in clinical or community-relevant human populations, controlled animal model experiments, and mechanistic work using cell preparations. Applicants can propose studies examining exposure to the whole e-cigarette aerosol as it is actually inhaled, or they can isolate and test specific components or constituents within the aerosol to determine which ingredients or byproducts may drive particular cardiovascular or pulmonary effects. Another explicitly encouraged area is deposition research, meaning projects that characterize where aerosols, particles, or chemical constituents settle in the respiratory tract and how that deposition pattern translates into downstream consequences for lung function, airway biology, and cardiovascular outcomes.
From an administrative standpoint, this opportunity is offered as an NIH R01 (research project grant) mechanism within the broader health research activity category. It is associated with CFDA numbers 93.837 and 93.838. The source record lists an award ceiling of $300,000, though the expected number of awards is not specified in the provided information. The original closing date for applications was 2017-08-01, and the opportunity record was created on 2016-09-23, placing it in the period when federal research agencies were intensifying efforts to understand the rapidly evolving e-cigarette product landscape and its potential health impacts.
Eligibility is expansive across U.S.-based organizations and governmental units. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; and a range of nonprofit entities both with and without 501(c)(3) status (when not an institution of higher education). The FOA also permits applications from for-profit organizations (other than small businesses) and from small businesses, and it includes an “Others” category that can cover additional qualifying entity types under NIH policy.
The announcement also highlights additional categories of eligible applicants, emphasizing inclusion of institutions and organizations that serve historically underrepresented or special populations. These specifically named groups include Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, Indian/Native American tribal governments other than federally recognized entities, and U.S. territories or possessions. At the same time, the FOA draws a firm boundary around foreign involvement: non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply; non-domestic components of U.S. organizations are not eligible; and foreign components, as defined by the NIH Grants Policy Statement, are not allowed. In practical terms, the work must be proposed and carried out within an allowable domestic framework without foreign components as part of the project structure.
Overall, the opportunity is meant to accelerate credible, mechanistic-to-clinical research that clarifies how e-cigarette aerosols and their constituents affect cardiovascular and pulmonary biology and health, including where inhaled materials deposit in the airways and what those exposure patterns mean for heart and lung outcomes. The R01 mechanism signals an expectation of a well-developed, hypothesis-driven research plan with clear significance, strong methods, and the potential to meaningfully advance understanding of e-cigarette-related cardiopulmonary risks.Apply for RFA HL 17 021
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Cardiovascular and Pulmonary Research on E-Cigarettes (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.837, 93.838.
- This funding opportunity was created on 2016-09-23.
- Applicants must submit their applications by 2017-08-01. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $300,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the name and number of this funding opportunity?
This opportunity is titled Cardiovascular and Pulmonary Research on E-Cigarettes (R01) and is identified as RFA-HL-17-021.
What type of grant is this?
It is an NIH R01 (Research Project Grant) mechanism, described as a discretionary research grant intended to support a well-developed, hypothesis-driven project.
What is the main purpose of this FOA?
The central aim is to spur rigorous, non-cancer-focused research on how electronic cigarette exposure affects the heart, blood vessels, and lungs, including outcomes that may arise in one system or through combined heart-lung interactions.
Is cancer-related research within scope?
The opportunity is described as non-cancer-focused, with emphasis placed on cardiovascular and pulmonary physiologic and health outcomes linked to e-cigarette exposure.
What kinds of health outcomes is NIH looking to clarify?
The FOA seeks clearer evidence on cardiovascular and pulmonary physiologic and health outcomes associated with e-cigarette use, including outcomes that may appear in the cardiovascular system, the pulmonary system, or through interactions between the two.
How broad is the research scope?
The announcement is intentionally broad and encourages investigators to address real-world questions about exposure and harm mechanisms, without restricting projects to a single product type, population, or experimental approach.
What study settings and scientific approaches are allowed?
A wide range of strategies and settings are welcomed, including:
- Research in clinical or community-relevant human populations
- Controlled animal model experiments
- Mechanistic work using cell preparations
Can applicants study whole e-cigarette aerosol, specific constituents, or both?
Both are allowed. Applicants may propose studies of the whole e-cigarette aerosol as actually inhaled, or they may isolate and test specific components/constituents to identify which ingredients or byproducts may drive particular cardiovascular or pulmonary effects.
What is "deposition research" in the context of this FOA?
Deposition research is explicitly encouraged and refers to projects that characterize where aerosols, particles, or chemical constituents settle in the respiratory tract and how those deposition patterns relate to downstream consequences for lung function, airway biology, and cardiovascular outcomes.
Does the FOA restrict projects to one e-cigarette product type?
No. The FOA is broad by design and encourages research that addresses real-world exposure and mechanisms rather than limiting studies to a single product type.
Does the FOA restrict projects to a specific population?
No. The announcement encourages flexibility and does not limit studies to a single population, based on the information provided.
Does the FOA restrict projects to a specific experimental approach?
No. It explicitly welcomes multiple approaches, including human, animal, and cell-based mechanistic studies.
What activity category is associated with the opportunity?
It is listed under the broader health research activity category.
What CFDA numbers are associated with this FOA?
The opportunity is associated with CFDA 93.837 and CFDA 93.838.
What is the award ceiling listed for this opportunity?
The source record lists an award ceiling of $300,000.
How many awards are expected?
The expected number of awards is not specified in the information provided.
When was the opportunity record created?
The opportunity record was created on 2016-09-23.
What was the original application closing date?
The original closing date for applications was 2017-08-01.
What types of U.S. government entities are eligible to apply?
Eligibility includes a broad set of U.S.-based governmental units, including:
- State governments
- County governments
- City or township governments
- Special district governments
Are educational institutions eligible?
Yes. Eligible applicants include:
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
Are tribal governments and tribal organizations eligible?
Yes. Eligible applicants include federally recognized Native American tribal governments and tribal organizations that are not federally recognized. The FOA also emphasizes inclusion of Indian/Native American tribal governments other than federally recognized entities.
Are nonprofits eligible to apply?
Yes. Eligibility includes nonprofit entities with 501(c)(3) status and nonprofits without 501(c)(3) status (when not an institution of higher education), based on the information provided.
Are for-profit organizations eligible?
Yes. The FOA permits applications from for-profit organizations (other than small businesses) and also from small businesses.
Are public housing authorities eligible?
Yes. Eligible applicants include public housing authorities/Indian housing authorities.
What is meant by the "Others" eligibility category?
The FOA includes an "Others" category that may cover additional qualifying entity types under NIH policy, as described in the information provided.
Does the FOA highlight any special categories of eligible applicants?
Yes. It emphasizes inclusion of institutions and organizations serving historically underrepresented or special populations, including:
- Alaska Native and Native Hawaiian Serving Institutions
- Asian American Native American Pacific Islander Serving Institutions (AANAPISIs)
- Hispanic-serving Institutions
- Historically Black Colleges and Universities (HBCUs)
- Tribally Controlled Colleges and Universities (TCCUs)
- Faith-based or community-based organizations
- Eligible federal agencies
- Regional organizations
- U.S. territories or possessions
Are non-U.S. (foreign) institutions eligible to apply?
No. The FOA states that non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply.
Can a U.S. organization include a non-domestic component as part of the project?
No. The FOA states that non-domestic components of U.S. organizations are not eligible.
Are foreign components allowed in the project structure?
No. The FOA indicates that foreign components, as defined by the NIH Grants Policy Statement, are not allowed. The work must be proposed and carried out within an allowable domestic framework without foreign components.
What does the R01 mechanism imply about expectations for the application?
The R01 mechanism signals an expectation of a well-developed, hypothesis-driven research plan with clear significance, strong methods, and the potential to meaningfully advance understanding of e-cigarette-related cardiopulmonary risks.
What is the overall goal of the opportunity in plain terms?
Overall, the FOA is meant to accelerate credible research, from mechanistic to clinical, that clarifies how e-cigarette aerosols and their constituents affect cardiovascular and pulmonary biology and health, including how deposition in the airways may relate to heart and lung outcomes.
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