Opportunity Information: Apply for PAR 23 297
The National Institutes of Health (NIH) is offering a discretionary grant opportunity titled "Opportunities for HIV Cure Strategies at the Time of ART Initiation (R01 Clinical Trial Not Allowed)" under funding opportunity number PAR-23-297. This opportunity supports research projects in the health arena (CFDA/Assistance Listing numbers 93.242, 93.855, and 93.865) using the NIH R01 grant mechanism. The core focus is on advancing HIV cure-oriented strategies that can be given right when a person starts combination antiretroviral therapy (cART), and/or when cART is restarted after an analytical treatment interruption (ATI). The long-term aim is sustained treatment-free remission, meaning durable control of HIV without needing ongoing antiretroviral drugs.
The NOFO is specifically oriented toward identifying and developing interventions that are practical and biologically rational at these key treatment transition points: initial ART initiation and ART re-initiation after an interruption. The scientific premise behind this emphasis is that very early treatment windows and carefully managed restart periods may offer unique opportunities to shape the HIV reservoir, the immune response, and viral rebound dynamics in ways that could improve the chances of long-lasting remission. In other words, this funding line is looking for cure strategies that fit naturally into the clinical timeline when ART is first introduced or reintroduced, rather than approaches that require long lead-in periods or are only feasible after many years on therapy.
As indicated by the title, clinical trials are not allowed under this announcement. That generally means applicants should propose pre-clinical studies, translational research, mechanistic human studies that do not meet the definition of a clinical trial, and other kinds of experimental or observational work aimed at generating strong evidence for candidate cure strategies. The intent is to build or refine strategies that could later be tested in clinical trial settings, but the work proposed under this particular R01 must stay within the non-clinical-trial boundaries NIH sets for this funding opportunity.
Eligibility is broad and includes many types of U.S.-based organizations and certain non-U.S. entities. Eligible applicants listed include state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations other than federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (as long as they are not institutions of higher education in those categories); for-profit organizations (other than small businesses); small businesses; and other entities. The NOFO also highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; eligible federal agencies; U.S. territories or possessions; regional organizations; and non-domestic (non-U.S.) entities, meaning foreign organizations may apply as well.
Key administrative details provided include an original closing date of 2026-09-07 and a creation date of 2023-09-20. The award ceiling and expected number of awards are not specified in the provided source information, so applicants would need to consult the full NIH posting for budget expectations, potential award sizes, and any institute- or center-specific guidance. Overall, the opportunity is designed to stimulate well-justified, cure-focused research that can realistically be deployed at the moment ART begins or resumes, with the strategic endpoint of enabling people living with HIV to maintain viral suppression without continuous therapy.Apply for PAR 23 297
- The National Institutes of Health in the health, income security and social services sector is offering a public funding opportunity titled "Opportunities for HIV Cure Strategies at the Time of ART Initiation (R01 Clinical Trial Not Allowed)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242, 93.855, 93.865.
- This funding opportunity was created on 2023-09-20.
- Applicants must submit their applications by 2026-09-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Down Syndrome Cohort Research Sites (DS-CRS) for the Down Syndrome Cohort Study Program (DS-CDP) across the lifespan for the INCLUDE Project (U01 Clinical Trial Not Allowed) Apply for RFA OD 24 003 Funding Number: RFA OD 24 003 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $300,000 |
| Long-Acting Drug Delivery Systems for ART Optimization in Children Living with HIV-1 II (LADDS II) (R61/R33 Clinical Trial Not Allowed) Apply for RFA AI 23 061 Funding Number: RFA AI 23 061 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $850,000 |
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| BRAIN Initiative: Research on the Ethical Implications of Advancements in Neurotechnology and Brain Science (R21 Clinical Trial Optional) Apply for RFA MH 25 171 Funding Number: RFA MH 25 171 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $275,000 |
| INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) Predoctoral to Postdoctoral Fellow Transition Award (F99/K00 Clinical Trial Not Allowed) Apply for RFA OD 24 007 Funding Number: RFA OD 24 007 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
| Optimizing Health of Children and Adolescents with Perinatal HIV Exposure (U19 Clinical Trial Optional) Apply for RFA HD 25 004 Funding Number: RFA HD 25 004 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
| Using Archived Data and Specimen Collections to Advance Maternal and Pediatric HIV/AIDS Research (R21 - Clinical Trial Not Allowed) Apply for RFA HD 25 009 Funding Number: RFA HD 25 009 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $275,000 |
| Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Centers (MDSRC) (P50 Clinical Trial Optional) Apply for RFA AR 25 002 Funding Number: RFA AR 25 002 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $1,000,000 |
| NIH HEAL Initiative: Coordinated Approaches to Pain Care in Health Care Systems (UG3/UH3 - Clinical Trial Optional) Apply for RFA NS 24 041 Funding Number: RFA NS 24 041 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
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| Advancement and Innovation in Measurement of Language Development and Predictors (R01 Clinical Trial Not Allowed) Apply for PAR 24 243 Funding Number: PAR 24 243 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
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