Opportunity Information: Apply for PAR 25 094
The National Cancer Institute (NCI), part of the National Institutes of Health (NIH), is soliciting research applications for an R01 grant opportunity focused on understanding how climate change affects cancer across the full cancer control continuum. The funding opportunity is titled "Impacts of climate change across the cancer control continuum (R01 Clinical Trial Optional)" and is released under Funding Opportunity Number PAR-25-094. The overarching aim is to support rigorous, research-driven work that clarifies where, how, and for whom climate-related environmental and societal changes influence cancer risk, prevention, detection, treatment, survivorship, and broader outcomes. Because this is an R01 mechanism, projects are generally expected to be well-developed and hypothesis-driven (or strongly conceptually grounded), with the scale and resources to produce meaningful, generalizable evidence. The "Clinical Trial Optional" designation means applicants may propose studies that do not include a clinical trial, or they may include a clinical trial if it is scientifically justified and aligns with NIH requirements for clinical trial oversight.
This opportunity is categorized as a discretionary grant program with an activity focus spanning education and health (CFDA 93.396). While the short description is brief, the title and NCI framing point to a broad scope: research can be anchored anywhere along the cancer control continuum, so long as climate change is a central driver or modifier of the cancer-related question. In practical terms, that can include investigating how rising temperatures, worsening air quality and wildfire smoke, changing patterns of ultraviolet exposure, shifts in infectious disease ecology, extreme weather events, flooding, drought, food and water insecurity, or climate-related disruptions to housing and healthcare access may affect cancer incidence, screening and diagnosis timing, continuity of care, treatment complications, survivorship needs, and mortality. It can also include understanding how climate change may amplify existing disparities, for example by disproportionately affecting communities that already face structural barriers to prevention and care.
A major emphasis implicit in this topic area is the need to connect climate exposures and climate-driven events to measurable cancer outcomes and real-world cancer control systems. Competitive applications typically clarify the climate-related exposure pathway (for example, chronic particulate exposure from longer wildfire seasons, or heat-related interruptions in healthcare delivery), specify the relevant population and setting (including geographic and community context), identify the cancer-related outcome(s) of interest, and explain why the proposed methods are appropriate for isolating climate impacts from other influences. Strong projects often integrate data sources across disciplines, such as environmental monitoring, geospatial and remote sensing products, electronic health records, cancer registries, claims data, cohort studies, and community-level vulnerability indices. Depending on the research question, projects might also involve intervention development and testing, implementation strategies, or health services research designed to reduce climate-related disruptions in cancer care, which is where a clinical trial component could be relevant.
The eligibility for this NOFO is broad and includes a wide range of domestic and international organizations. Eligible applicants listed include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities and Indian housing authorities; Native American tribal organizations other than federally recognized tribal governments; nonprofits with and without 501(c)(3) status (excluding institutions of higher education in those categories as specified); for-profit organizations other than small businesses; small businesses; and other entities. The NOFO also explicitly highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, non-domestic (non-U.S.) entities (foreign organizations), Indian/Native American Tribal Governments that are not federally recognized, and U.S. territories or possessions. This wide eligibility signals that NCI is encouraging participation from diverse institutional types, including those embedded in communities that may experience disproportionate climate burdens and cancer disparities.
Key administrative details provided include an original application closing date of 2026-05-07 and a creation date of 2024-11-18. The award ceiling and expected number of awards are not specified in the provided source data, which usually means applicants should consult the full NOFO text and NIH policy pages for budget guidance, project period expectations, and any institute-specific constraints or preferences. As with most NIH R01 opportunities, budgets are typically justified based on the scope of work, and applications are evaluated through NIH peer review criteria, with added attention to whether the project is well aligned to the stated priority area of climate change impacts across cancer control.
Overall, this grant opportunity is best viewed as a call for interdisciplinary cancer research that treats climate change not as background context but as a key explanatory factor shaping cancer outcomes and cancer care systems. Projects that can clearly link climate-driven exposures or disruptions to actionable cancer control insights, especially those that identify modifiable points for prevention, preparedness, adaptation, or equitable service delivery, are likely to fit well within the intent of PAR-25-094.Apply for PAR 25 094
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Impacts of climate change across the cancer control continuum (R01 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.396.
- This funding opportunity was created on 2024-11-18.
- Applicants must submit their applications by 2026-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal:
Frequently Asked Questions (FAQs)
What is this funding opportunity?
This is a National Cancer Institute (NCI), National Institutes of Health (NIH) R01 funding opportunity titled "Impacts of climate change across the cancer control continuum (R01 Clinical Trial Optional)" under Funding Opportunity Number PAR-25-094. It solicits research applications that examine how climate change affects cancer across the full cancer control continuum.
Which agency is offering this grant?
The opportunity is offered by the National Cancer Institute (NCI), which is part of the National Institutes of Health (NIH).
What grant mechanism is used?
The mechanism is an NIH R01 research project grant. Projects are generally expected to be well-developed and either hypothesis-driven or strongly conceptually grounded, with enough scale and resources to generate meaningful and generalizable evidence.
What does "Clinical Trial Optional" mean for PAR-25-094?
"Clinical Trial Optional" means an application may propose research that does not include a clinical trial, or it may include a clinical trial if the trial is scientifically justified and aligns with NIH requirements for clinical trial oversight.
What is the main goal of this opportunity?
The overarching aim is to support rigorous, research-driven work that clarifies where, how, and for whom climate-related environmental and societal changes influence cancer risk, prevention, detection, treatment, survivorship, and broader outcomes.
What parts of the cancer control continuum are in scope?
The scope spans the full cancer control continuum, including cancer risk and incidence, prevention, screening and early detection, diagnosis timing, treatment and continuity of care, treatment complications, survivorship, and mortality and broader outcomes, as long as climate change is a central driver or modifier of the cancer-related question.
What kinds of climate change factors or events can be studied?
Examples described include rising temperatures, worsening air quality and wildfire smoke, changing ultraviolet exposure patterns, shifts in infectious disease ecology, extreme weather events, flooding, drought, food and water insecurity, and climate-related disruptions to housing and healthcare access.
Do projects need to tie climate exposures to measurable cancer outcomes?
Yes. A major emphasis in this topic area is connecting climate exposures and climate-driven events to measurable cancer outcomes and real-world cancer control systems.
What makes an application a strong fit based on the description provided?
Competitive applications typically (1) clarify the climate-related exposure pathway (for example, chronic particulate exposure from longer wildfire seasons or heat-related interruptions in healthcare delivery), (2) specify the relevant population and setting (including geographic and community context), (3) identify the cancer-related outcome(s) of interest, and (4) explain why the proposed methods are appropriate for isolating climate impacts from other influences.
Can the research focus on healthcare delivery and disruptions in cancer care?
Yes. The scope includes work on climate-related disruptions to housing and healthcare access, screening and diagnosis timing, continuity of care, and treatment complications. Health services research and implementation strategies designed to reduce climate-related disruptions in cancer care are explicitly noted as potentially relevant.
Are interventions allowed, and could they involve clinical trials?
Projects may involve intervention development and testing or implementation strategies if they fit the research question. A clinical trial component could be relevant in those cases, consistent with the "Clinical Trial Optional" designation and NIH clinical trial requirements.
What data sources or methods are suggested as relevant?
The description highlights integrating data sources across disciplines, including environmental monitoring, geospatial and remote sensing products, electronic health records, cancer registries, claims data, cohort studies, and community-level vulnerability indices.
Is research on disparities and equity within scope?
Yes. The opportunity notes that climate change may amplify existing disparities, including disproportionate impacts on communities that already face structural barriers to prevention and care.
What is the CFDA number and program category mentioned?
The opportunity is described as a discretionary grant program with an activity focus spanning education and health, with CFDA 93.396.
Who is eligible to apply?
Eligibility is broad and includes domestic and international organizations. Eligible applicants listed include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities and Indian housing authorities; Native American tribal organizations other than federally recognized tribal governments; nonprofits with and without 501(c)(3) status (excluding institutions of higher education in those categories as specified); for-profit organizations other than small businesses; small businesses; and other entities.
Are foreign (non-U.S.) organizations eligible?
Yes. The eligible applicant types explicitly include non-domestic (non-U.S.) entities (foreign organizations).
Are U.S. territories or possessions eligible?
Yes. U.S. territories or possessions are explicitly highlighted among eligible applicant types.
Are Tribal and Tribal-serving organizations and institutions included?
Yes. The eligibility list includes federally recognized Native American tribal governments, tribal organizations other than federally recognized tribal governments, Indian/Native American Tribal Governments that are not federally recognized, Tribally Controlled Colleges and Universities (TCCUs), and housing authorities serving Native communities.
Are minority-serving institutions explicitly encouraged or eligible?
Yes. The NOFO highlights Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are explicitly highlighted as eligible applicant types.
Are federal agencies eligible to apply?
Yes. Eligible federal agencies are explicitly highlighted among eligible applicant types.
What is the application due date provided?
The original application closing date provided is 2026-05-07.
What is the creation date listed for this opportunity?
The creation date provided is 2024-11-18.
Is there an award ceiling listed?
No. The award ceiling is not specified in the provided information.
Is the expected number of awards listed?
No. The expected number of awards is not specified in the provided information.
How should applicants think about budgets and project scale based on what is provided?
The provided description notes that, as with most NIH R01 opportunities, budgets are typically justified based on the scope of work. Since no award ceiling or number of awards is listed in the provided source data, applicants would typically need to consult the full NOFO text and NIH policy pages for budget guidance and project period expectations.
How will applications be evaluated?
The description indicates applications are evaluated through NIH peer review criteria, with added attention to alignment with the stated priority area: climate change impacts across the cancer control continuum.
Does the opportunity emphasize interdisciplinary work?
Yes. It is framed as a call for interdisciplinary cancer research that integrates climate-related exposures or disruptions with cancer outcomes and cancer control systems, potentially combining environmental, geospatial, clinical, and population-level data sources.
What does it mean to treat climate change as a "central driver or modifier" in the research?
Based on the description, it means climate change should not be incidental background context. The proposed study should make climate-related environmental or societal changes a key explanatory factor in the cancer-related question and should aim to link those climate-driven exposures or disruptions to cancer outcomes or cancer control processes.
What types of outcomes could be considered "actionable" within this NOFO's intent?
The description suggests a good fit includes research that produces cancer control insights tied to prevention, preparedness, adaptation, or equitable service delivery, particularly where the work identifies modifiable points to reduce climate-related risks or disruptions.
Browse more opportunities from the same category: Education, Health
Next opportunity: Limited Competition: Competing Revisions to Support Clinical Trials in Somatic Cell Genome Editing (U19 Clinical Trial Required)
Previous opportunity: Development and Application of PET and SPECT Imaging Ligands as Biomarkers for Drug Discovery and for Pathophysiological Studies of CNS Disorders (R01 Clinical Trial Optional)
Applicant Portal:
Are you interested in learning about about how to apply for this government funding opportunity? You can create a free applicant account and receive instant access to our applicant portal that many business owners like you have benefited from.
Apply for PAR 25 094
Applicants also applied for:
Applicants who have applied for this opportunity (PAR 25 094) also looked into and applied for these:
| Funding Opportunity |
|---|
| NCI Mentored Research Scientist Development Award to Promote Diversity (K01 Independent Clinical Trial Not Allowed) Apply for PAR 24 316 Funding Number: PAR 24 316 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NIDA Research Education Program for Clinical Researchers and Clinicians (R25 Clinical Trial Not Allowed) Apply for PAR 25 204 Funding Number: PAR 25 204 Agency: National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| Impacts of climate change across the cancer control continuum (R21 Clinical Trial Optional) Apply for PAR 25 152 Funding Number: PAR 25 152 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Basic Research in Cancer Health Disparities (R21 Clinical Trial Not Allowed) Apply for PAR 25 244 Funding Number: PAR 25 244 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Basic Research in Cancer Health Disparities (R01 Clinical Trial Not Allowed) Apply for PAR 25 243 Funding Number: PAR 25 243 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Investigator Initiated Innovation in Computational Genomics and Data Science (R21 Clinical Trial Not Allowed) Apply for PAR 25 229 Funding Number: PAR 25 229 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Investigator Initiated Innovation in Computational Genomics and Data Science (R01 Clinical Trial Not Allowed) Apply for PAR 25 228 Funding Number: PAR 25 228 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R21 Clinical Trials Not Allowed) Apply for PAR 25 096 Funding Number: PAR 25 096 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R01 Clinical Trial Not Allowed) Apply for PAR 25 095 Funding Number: PAR 25 095 Agency: National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| NCMRR Early Career Research Award (R03 Clinical Trial Optional) Apply for PAR 25 124 Funding Number: PAR 25 124 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Mechanisms that Impact Cancer Risk with Use of Incretin Mimetics (R21 Clinical Trial Not Allowed) Apply for PAR 25 070 Funding Number: PAR 25 070 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Mechanisms that Impact Cancer Risk with Use of Incretin Mimetics (R01 Clinical Trial Optional) Apply for PAR 25 069 Funding Number: PAR 25 069 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Advancing Genomic Medicine Research (R21 Clinical Trial Optional) Apply for RFA HG 25 003 Funding Number: RFA HG 25 003 Agency: National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
| Research Opportunities in Established Cancer Epidemiology Cohort Studies (U01 Clinical Trial Not Allowed) Apply for PAR 25 275 Funding Number: PAR 25 275 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Advancing Genomic Medicine Research (R01 Clinical Trial Optional) Apply for RFA HG 25 002 Funding Number: RFA HG 25 002 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Biology of Bladder Cancer (R01 Clinical Trial Optional) Apply for PAR 25 129 Funding Number: PAR 25 129 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Biology of Bladder Cancer (R21 Clinical Trial Optional) Apply for PAR 25 128 Funding Number: PAR 25 128 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Chemical Countermeasures Research Program (CCRP) Initiative: Basic Research on The Deleterious Effects of Acute Exposure to Ultra-Potent Synthetic (UPS) Opioids (R01 Clinical Trial Not Allowed) Apply for RFA DA 26 034 Funding Number: RFA DA 26 034 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| NCI Pathway to Independence Award (K99/R00 Clinical Trial Not Allowed) Apply for PAR 25 135 Funding Number: PAR 25 135 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Co-infection and Cancer (R21 Clinical Trial Not Allowed) Apply for PAR 25 083 Funding Number: PAR 25 083 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
Grant application guides and resources
It is always free to apply for government grants. However the process may be very complex depending on the funding opportunity you are applying for. Let us help you!
Apply for Grants
Inside Our Applicants Portal
Access Applicants Portal
- Grants Repository - Access current and historic funding opportunities with ease. Thousands of funding opportunities are published every week. We can help you sort through the database and find the eligible ones to apply for.
- Applicant Video Guides - The grant application process can be challenging to follow. We can help you with intuitive video guides to speed up the process and eliminate errors in submissions.
- Grant Proposal Wizard - We have developed a network of private funding organizations and investors across the United States. We can reach out and submit your proposal to these contacts to maximize your chances of getting the funding you need.
Premium leads for funding administrators, grant writers, and loan issuers
Thousands of people visit our website for their funding needs every day. When a user creates a grant proposal and files for submission, we pass the information on to funding administrators, grant writers, and government loan issuers.
If you manage government grant programs, provide grant writing services, or issue personal or government loans, we can help you reach your audience.
Learn More
Request more information:
Would you like to learn more about this funding opportunity, similar opportunities to "PAR 25 094", eligibility, application service, and/or application tips? Submit an inquiry below:
Don't forget to subscribe to our grant alerts mailing list to receive weekly alerts on new and updated grant funding opportunities like this one in your email.